Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
colonic cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
LNCaP cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
prostate cancer cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Homo sapiens | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
FAS | - |
Homo sapiens |
fatty acid synthase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mithramycin inhibits FAS expression, transfection of transcription factor Sp1 siRNA suppresses FAS expression | down |
Homo sapiens | transcription factor Sp3 and Sp4 siRNAs do not affect FAS expression | additional information |
Homo sapiens | 17beta-estradiol increases FAS expression, estrogen induces FAS expression | up |